| Bsolus | |
| Bug Group | Lisbon |
| Build Up Labs | Lisbon |
| Buildcode | |
| Builtrix | Lisbon |
| Bullet Solutions | |
| Buzina | |
| Buzz Design & IT | |
| Buzzvel | |
| Byclosure, Lda | Lisbon |
| BYDAS, Digital Communication Agency, Lda | Porto |
| Byld | |
| BYND | Lisbon |
| Bynet | Porto |
| BySide | Porto |
| ByteNuts | |
| BytePitch | Porto |
| C-mo Medical Solutions | Lisbon |
| C2C NewCap | Lisbon |
| Caixa Capital | Lisbon |
| Caixa Geral de Depósitos, S.A. | |
| Caixa Mágica Software | Lisbon |
| CaixaBI | |
| Camâra do Comércio Portugal-Israel | |
| Carnegie Mellon University Portugal | Lisbon |
| Casafari Europe Ltd | Lisbon |
| Católica Lisbon School of Business & Economics | Lisbon |
| CEC | Lisbon |
| Cegid Vendus | |
| CellmAbs | Oeste |
| Centre for Informatics and Systems of the University of Coimbra | |
| Centro de Computacao Grafica | Ave |
| Centro Internacional de Matemática | Lisbon |
| Centro Nacional de Cibersegurança Portugal | Lisbon |
| Champalimaud Foundation | |
| Chilltime Games | |
| China Facture | Lisbon |
| Chitas Web Solutions | |
| chrome.pt | Lisbon |
| Ciberbit | Porto |
| CimSoft | Porto |
| Circletec | |
| Circular Unity | Lisbon |
| City as a Platform | Lisbon |
| Claranet Portugal | |
| Claranet Portugal S.A. | Lisbon |
| Classinfor, Lda | Lisbon |
| Cleanwatts | Região de Coimbra |
| Clevernet | Lisbon |
| Clientscape | Lisbon |