| Security Meter | Giza |
| Select Digital Agency | |
| SemiColon Ltd | |
| Senior Web Designer | Cairo |
| SEO Egypt | |
| SEOS7 | |
| Sequence Ventures | Giza |
| Seven Dynamic | |
| Shark Clicks | |
| Shark4Host.com | Cairo |
| Shift e-business | Cairo |
| ShipBlu Technology | Cairo |
| Shopless Business Solutions | |
| Silicon Mind | |
| Silicon Waha | |
| Silicon21 | Cairo |
| SilverKey Technologies | Giza |
| Sinai University | |
| Smart Cards Applications Company | Cairo |
| Smart Villages Company | Cairo |
| Smartec | Cairo |
| SmartTech | |
| Softex Software House | Cairo |
| SoftLock | Cairo |
| Software Engineering Competence Center | Cairo |
| Sohag University | Cairo |
| South Valley University | |
| Spark Systems | |
| Spirula Systems | Alexandria |
| SPlus Marketing S.A.E. | |
| Sprints | |
| Startup Haus Cairo | Cairo |
| Startup Scene | Cairo |
| Startups of Alex | Alexandria |
| StrategyConsult | Cairo |
| STS | Cairo |
| Suez Canal University | |
| Sumerge Software Solutions | Giza |
| Super Star Group | Giza |
| Survtech Technology Services | |
| SWISOdev | |
| Sympl | Cairo |
| Synapse Analytics | Cairo |
| Systel.com.eg | Cairo |
| Systems Engineering of Egypt | Cairo |
| Systems integrated solutions | Giza |
| Systems Management Consultants | Cairo |
| TAC Universe | Cairo |
| Tanta University | |
| Tanzeem | |